Retinosquisis y desprendimiento neurosensorial peripapilar asociado a glaucoma focal avanzado / Retinoschisis and neurosensory detachment in advanced focal glaucoma

Caso clínico: Mujer de 71 años, diagnosticada de glaucoma primario de ángulo abierto normotensional; presentó de forma asintomática, en el ojo con daño glaucomatoso más avanzado, una retinosquisis peripapilar temporal con desprendimiento de retina seroso subyacente, mayor en la porción inferior del disco donde existía un defecto focal. Discusión: Aunque las fosetas congénitas son las que más se asocian con la retinosquisis peripapilar, esta también puede surgir a partir de defectos adquiridos en las proximidades de las papilas glaucomatosas. Dependiendo de su extensión esta complicación puede ser asintomática, por lo que su prevalencia podría ser mayor de la publicada (AU)

Clinical case: A 71-year-old woman with normotensive primary open-angle glaucoma presented with an asymptomatic temporal peripapillary retinoschisis, associated with serous retinal detachment in the eye with the more advanced glaucoma. It was located at the inferior pole of the optic disc, in the proximity of a glaucomatous focal disc defect. Discussion: Although congenital optic pits are strongly related with juxta-papillary retinoschisis, retinoschisis can also arise from acquired defects in the proximity of glaucomatous optic discs. As symptoms depend on the extent of the retinoschisis, the prevalence of this complication could be greater than that reported in glaucomatous eyes (AU)

Retinoschisis and neurosensory detachment in advanced focal glaucoma. / Retinosquisis y desprendimiento neurosensorial peripapilar asociado a glaucoma focal avanzado.

CLINICAL CASE: A 71-year-old woman with normotensive primary open-angle glaucoma presented with an asymptomatic temporal peripapillary retinoschisis, associated with serous retinal detachment in the eye with the more advanced glaucoma. It was located at the inferior pole of the optic disc, in the proximity of a glaucomatous focal disc defect. DISCUSSION: Although congenital optic pits are strongly related with juxta-papillary retinoschisis, retinoschisis can also arise from acquired defects in the proximity of glaucomatous optic discs. As symptoms depend on the extent of the retinoschisis, the prevalence of this complication could be greater than that reported in glaucomatous eyes.

Aplicaciones clínicas de la toxina botulínica en el estrabismo: estudio de las inyecciones realizadas durante un año en un hospital general / Botulinum toxin uses in strabismus: A review of the injections performed during one year in a general hospital

OBJETIVO: Analizar las indicaciones, dosis y eficacia de las inyecciones de toxina botulínica A en el departamento de Estrabología. MÉTODO: En este estudio prospectivo, 28 pacientes diagnosticados de estrabismo fueron tratados con toxina botulínica. Se recopilaron los pacientes tratados en 2013 en el Hospital Rey Juan Carlos (Móstoles) para estudiar las indicaciones, la dosis empleada, y se analizaron los resultados de la última revisión, tanto en niños como en adultos, con un seguimiento mínimo de 14 meses. RESULTADOS: Se recogieron datos de 11 niños, 6 mujeres (54,5%), y 17 adultos, 11 varones (64%). La edad media fue 4,42 ± 3,48 años y 58,71 ± 18,07 años en niños y adultos respectivamente. En ambos grupos la mayoría de los casos eran endotropias (81,8% en niños y 47,1% en adultos), aunque el grupo de adultos presentaba enfermedades más heterogéneas incluyendo 4 pacientes con exotropía (26,5%), 4 con hipertropía (26,5%) y uno con nistagmo aislado (5,9%). La media de inyecciones en niños fue de 1,45 ± 0,93, aunque el 72,7% recibieron una única inyección; en el grupo de adultos la media de inyecciones fue de 3,27 ± 1,41. Se encontró una diferencia estadísticamente significativa en la comparación de tropia y foria prepostinyección en niños y adultos (p < 0,05). En ambos grupos hubo una mejoría significativa en el tortícolis postinyección comparado con el previo (p < 0,05). En 4 niños pudimos detectar una mejoría en la estereoagudeza. Dos niños (18,2%) y 5 adultos (29,4%) precisaron intervención quirúrgica posterior. Ocho adultos (49,1%) presentaban diplopia en posición primaria de la mirada, que se resolvió en 6 casos con inyecciones de toxina, pero 2 necesitaron cirugía para la corrección de la diplopia. Las diferencias entre tropia y foria pre- y postintervención fueron estadísticamente significativas (p < 0,05), así como las diferencias entre el tortícolis pre- y postinyección. En 4 casos se pudo detectar mejoría en la estereoagudeza. CONCLUSIONES: La toxina botulínica es un fármaco muy útil en el estrabismo, con mejores resultados sensoriales y motores en los niños, pero eficaz como tratamiento sintomático en algunos casos de estrabismo en adultos

OBJECTIVE: To analyse the indications, dosage and efficacy of botulinum toxin A injection performed in patients in a Strabismus Department. METHODS: In this prospective study, botulinum toxin A was injected into 28 patients diagnosed with strabismus. Data was obtained from the records of patients that were evaluated during 2013 in the Strabismus Unit of Rey Juan Carlos Hospital (Móstoles, Madrid, Spain) in order to assess the indications and dosage of botulinum toxin A use in strabismus, as well as its clinical effect and differences in paediatric and adult patients. The outcomes in the last visit, at least 14 months after the injections, were analysed. RESULTS: An analysis was performed on the data from 11 children, 6 females (54.5%), and 17 adults, 11 males (64%). The mean age was 4.42 ± 3.48 years and 58.71 ± 18.07 years in the children and adult groups, respectively. The majority of cases in both groups were esotropia (81.8% in children and 47.1% in adults). However the pathologies in the adult group were quite heterogeneous, including 4 patients with exotropia (26.5%), 4 with hypertropia (26.5%), and one with isolated nystagmus (5.9%). The mean number of the botulinum toxin injections in children was 1.45 ± 0.93, although 72.7% received a single injection. In the adult group, the mean number of injections was 3.27 ± 1.41. There was a statistically significant difference between pre- and post-injection in the tropia and phoria measurements in children and adults group (P<.05). In both groups there was a statistically significant improvement in post-injection torticollis when compared with the pre-injection measurement (P<.05). An improvement in the stereoacuity could be detected in 4 children. Two children (18.2%) and 5 adults (29.4%) required subsequent surgical intervention. Eight adult patients (49.1%) complained of diplopia in the primary position, which was resolved in 6 cases with toxin injection, whereas 2 needed surgery for diplopia correction. CONCLUSIONS: Botulinum toxin is a very useful tool in the management of strabismus, obtaining better sensory and motor results in children, but it is also effective as a symptomatic treatment in some types of strabismus in adults

Botulinum toxin uses in strabismus: A review of the injections performed during one year in a general hospital.

OBJECTIVE: To analyse the indications, dosage and efficacy of botulinum toxin A injection performed in patients in a Strabismus Department. METHODS: In this prospective study, botulinum toxin A was injected into 28 patients diagnosed with strabismus. Data was obtained from the records of patients that were evaluated during 2013 in the Strabismus Unit of Rey Juan Carlos Hospital (Móstoles, Madrid, Spain) in order to assess the indications and dosage of botulinum toxin A use in strabismus, as well as its clinical effect and differences in paediatric and adult patients. The outcomes in the last visit, at least 14 months after the injections, were analysed. RESULTS: An analysis was performed on the data from 11 children, 6 females (54.5%), and 17 adults, 11 males (64%). The mean age was 4.42±3.48 years and 58.71±18.07 years in the children and adult groups, respectively. The majority of cases in both groups were esotropia (81.8% in children and 47.1% in adults). However the pathologies in the adult group were quite heterogeneous, including 4 patients with exotropia (26.5%), 4 with hypertropia (26.5%), and one with isolated nystagmus (5.9%). The mean number of the botulinum toxin injections in children was 1.45±0.93, although 72.7% received a single injection. In the adult group, the mean number of injections was 3.27±1.41. There was a statistically significant difference between pre- and post-injection in the tropia and phoria measurements in children and adults group (P<.05). In both groups there was a statistically significant improvement in post-injection torticollis when compared with the pre-injection measurement (P<.05). An improvement in the stereoacuity could be detected in 4 children. Two children (18.2%) and 5 adults (29.4%) required subsequent surgical intervention. Eight adult patients (49.1%) complained of diplopia in the primary position, which was resolved in 6 cases with toxin injection, whereas 2 needed surgery for diplopia correction. CONCLUSIONS: Botulinum toxin is a very useful tool in the management of strabismus, obtaining better sensory and motor results in children, but it is also effective as a symptomatic treatment in some types of strabismus in adults.

Glaucoma tardío por partículas de cristalino en síndrome de Marfan / Late onset lens particle glaucoma in Marfan syndrome

CASO CLÍNICO: Glaucoma agudo por partículas de cristalino, en una paciente afecta de síndrome de Marfan que presentaba un cristalino luxado en vítreo de más de 20 años de evolución. DISCUSIÓN: El síndrome de Marfan es un trastorno hereditario, autosómico dominante, del tejido conectivo causado por mutaciones del gen de la fibrilina. La ectopia lentis es la alteración ocular predominante y el criterio mayor de diagnóstico, siendo frecuente el desarrollo de glaucoma en los pacientes afectos de síndrome de Marfan. El caso que se expone es particular, dado que presenta una luxación completa, espontánea y bilateral del cristalino, que además desemboca en un glaucoma secundario de ángulo abierto por liberación de partículas del mismo desde la cámara vítrea

CASE REPORT: A case is presented of an acute onset lens particle glaucoma originating from a crystalline lens spontaneously dislocated into the vitreous for more than 20 years in a patient diagnosed with Marfan syndrome. DISCUSSION: Marfan syndrome is a connective tissue disorder with autosomal dominant inheritance caused by fibrillin gene mutation. Ectopia lentis is the predominant ocular abnormality and a major diagnostic criterion. An association between Marfan syndrome and glaucoma has also been demonstrated. The reported case is unusual in that a complete spontaneous lens dislocation to vitreous was present and progressed to secondary lens particle open angle glaucoma

[Late onset lens particle glaucoma in Marfan syndrome]. / Glaucoma tardío por partículas de cristalino en síndrome de Marfan.

CASE REPORT: A case is presented of an acute onset lens particle glaucoma originating from a crystalline lens spontaneously dislocated into the vitreous for more than 20 years in a patient diagnosed with Marfan syndrome. DISCUSSION: Marfan syndrome is a connective tissue disorder with autosomal dominant inheritance caused by fibrillin gene mutation. Ectopia lentis is the predominant ocular abnormality and a major diagnostic criterion. An association between Marfan syndrome and glaucoma has also been demonstrated. The reported case is unusual in that a complete spontaneous lens dislocation to vitreous was present and progressed to secondary lens particle open angle glaucoma.

[LASIK results of IntraLase femtosecond laser to correct myopia: efficacy, security and predictability]. / Resultados de LASIK realizado con láser de femtosegundo (IntraLase) para corrección de miopía: eficacia, predictibilidad y seguridad.

PURPOSE: To evaluate LASIK results obtained with the IntraLase femtosecond laser to correct myopia. METHODS: This was a prospective, single masked observer study. Flaps were created with the IntraLase femtosecond laser (FS). All laser procedures were performed by the same surgeon using the Technolas 217 excimer laser (Bausch & Lomb). We have analysed the uncorrected visual acuity (UCVA) at 1 day, 1 week, 1 month and 3 months after surgery and best spectacle-corrected visual acuity (BSCVA) after 3 months. RESULTS: 485 eyes with myopia were treated and their results evaluated. The mean preoperative sphere was of -3.9 D (SD 2.0) and a mean astigmatism of -0.9 D (SD 0.9) with BSCVA 1.1 (SD 0.1). The UCVA results were 0.94 (SD 0.1) at the first day postoperatively visit, 0.96 (SD 0.1) at first week, 1.00 (SD 0.1) at one month and 1.00 (SD 0.2) at 3 months. The refractive error at 3 months was -0.02 D (SD 0.3) and -0.1 D (SD 0.3) of myopia and astigmatism respectively. At 3 months 96.9% of eyes were within +/-1.00D and 93.6% of the eyes were within + 0.50 D. CONCLUSIONS: LASIK to correct myopia is a safe, effective and predictable procedure using IntraLase FS to create the flap.

Resultados de LASIK realizado con láser de femtosegundo (Intralase) para corrección de miopía: eficacia, predictibilidad y seguridad / Lasik results of intralase femtosecond laser to correct myopia: efficacy, security and predictability

Objetivo: Evaluar los resultados refractivos del LASIK utilizando láser de femtosegundo (Intralase) para tallar el colgajo corneal, en la corrección de miopía. Métodos: Se trata de un estudio prospectivo, observador enmascarado. Los colgajos fueron tallados con láser de femtosegundo (IntraLase). Todos los procedimientos láser fueron realizados por el mismo cirujano utilizando el láser Technolas 217 (Bausch & Lomb). Se evaluó la agudeza visual sin corrección (AVsc) al primer día, semana, primer y tercer mes después de la cirugía, así como la agudeza visual mejor corregida (AVCC) a los tres meses de la cirugía. Resultados: Evaluamos los resultados refractivos de LASIK en 485 ojos miopes. El defecto refractivo previo era de -3,9 D (DE 2,0) esfera y de -0,9 (DE 0,9) cilindro con una AVCC inicial de 1,1 (DE 0,1). Los resultados de la AVsc fueron de 0,94 (DE 0,1) al primer día postoperatorio, 0,96 (DE 0,1) a la aislasemana, 1,00 (DE 0,1) al mes y 1.00 (DE 0,2) a los 3 meses. La refracción manifiesta a los 3 meses fue de -0,02 D (DE 0,3) y -0,1 D (DE 0,3) de miopía y astigmatismo respectivamente. El 96,9% de los pacientes a los 3 meses estaban dentro de un equivalente esférico de ± 1,00 D y el 93,6% de los mismos se encontraban dentro de un equivalente esférico de ± 0,50 D. Conclusiones: Los resultados obtenidos en nuestra experiencia parecen demostrar que el LASIK realizado utilizando láser de femtosegundo, es un método seguro, eficaz y predecible para la corrección de miopía

Purpose: To evaluate LASIK results obtained with the IntraLase femtosecond laser to correct myopia. Methods: This was a prospective, single masked observer study. Flaps were created with the Intra- Lase femtosecond laser (FS). All laser procedures were performed by the same surgeon using the Technolas 217 excimer laser (Bausch & Lomb). We have analysed the uncorrected visual acuity (UCVA) at 1 day, 1 week, 1 month and 3 months after surgery and best spectacle-corrected visual acuity (BSCVA) after 3 months. Results: 485 eyes with myopia were treated and their results evaluated. The mean preoperative sphere was of -3.9 D (SD 2.0) and a mean astigmatism of -0.9 D (SD 0.9) with BSCVA 1.1 (SD 0.1). The UCVA results were 0.94 (SD 0.1) at the first day postoperatively visit, 0.96 (SD 0.1) at first week, 1.00 (SD 0.1) at one month and 1.00 (SD 0.2) at 3 months. The refractive error at 3 months was -0.02 D (SD 0.3) and -0.1 D (SD 0.3) of myopia and astigmatism respectively. At 3 months 96.9% of eyes were within ±1.00D and 93.6% of the eyes were within + 0.50 D. Conclusions: LASIK to correct myopia is a safe, effective and predictable procedure using IntraLase FS to create the flap

[Evaluation of the efficacy of long term topical steroid treatment to prevent regression after hyperopic LASIK]. / Valoración de la eficacia de tratamiento corticoideo tópico prolongado para prevenir regresión en LASIK hipermetrópico.

PURPOSE: To evaluate the efficacy of long-term versus short-term steroid treatment in preventing regression after hyperopic LASIK. MATERIAL AND METHODS: This is a prospective single masked study. Hyperopic patients who were candidates for LASIK surgery were randomized to be treated with one week (topical dexametasone) in control group or one month (topical dexametasone the first week and topical fluormetalone the next three weeks) in study group. The three month postoperative manifest refraction was compared between the two groups. RESULTS: 105 eyes were included in each group. The mean preoperative spherical equivalent was 3.17 D SD 2.82 D (standard deviation) and 3.39 D SD 2.65 D in the study and control group, respectively (p=0.6). The final manifest refraction in the three-month postoperative visit was 0.62 D SD 0.68 D and 0.6 D SD 0.3 D in the study and control group respectively (p=0.6). CONCLUSIONS: Long-term topical steroid therapy does not appear to improve the refractive result in hyperopic LASIK.

Valoración de la eficacia de tratamiento corticoideo tópico prolongado para prevenir regresión en LASIK hipermetrópico / Evaluation of the efficacy of long term topical steroid treatment to prevent regression after hyperopic LASIK

Objetivo: Evaluar la eficacia del tratamiento corticoideo tópico prolongado en pacientes operados de LASIK hipermetrópico.Material y métodos: Se realiza un estudio prospectivo observador enmascarado. Pacientes candidatos a cirugía LASIK para la corrección de baja y moderada hipermetropía fueron asignados aleatoriamente a recibir tratamiento tópico corticoideo (dexametasona) una semana (grupo control) o un mes (dexametasona la primera semana y fluorometalona las tres siguientes), en el grupo estudio. Se comparó la refracción final manifiesta en ambos grupos.Resultados: Analizamos 105 ojos en cada grupo (estudio y control). El equivalente esférico medio preoperatorio era 3,17 D DE 2,82 D (desviación estándar) y 3,39 D DE 2,65 D en el grupo estudio y control respectivamente (p=0,6). La refracción final manifiesta a los 3 meses era 0,62 D DE 0,68 D y 0,6 D DE 0,3 D en el grupo estudio y control respectivamente (p=0,6).Conclusión: La regresión refractiva tras LASIK hipermetrópico, no parece ser modulable por el mayor o menor tratamiento corticoideo tópico

Purpose: To evaluate the efficacy of long-term versus short-term steroid treatment in preventing regression after hyperopic LASIK.Material and methods: This is a prospective single masked study. Hyperopic patients who were candidates for LASIK surgery were randomized to be treated with one week (topical dexametasone) in control group or one month (topical dexametasone the first week and topical fluormetalone the next three weeks) in study group.The three month postoperative manifest refraction was compared between the two groups.Results: 105 eyes were included in each group. The mean preoperative spherical equivalent was 3.17 D SD 2.82 D (standard deviation) and 3.39D SD 2.65D in the study and control group, respectively (p=0.6). The final manifest refraction in the three-month postoperative visit was 0.62D SD 0.68D and 0.6D SD 0.3D in the study and control group respectively (p=0.6).Conclusions: Long-term topical steroid therapy does not appear to improve the refractive result in hyperopic LASIK

Relation between axial length of the eye and hypotensive effect of latanoprost in primary open angle glaucoma.

AIMS: To study the effect of axial length on the hypotensive effect of latanoprost in primary open angle glaucoma (POAG) in a prospective, observational study. METHODS: The authors measured axial length and baseline intraocular pressure (IOP) of 109 eyes with POAG, and then repeated the IOP measurements at 1, 3, and 6 months after starting treatment with latanoprost. RESULTS: The mean IOP level was significantly lower in eyes with a shorter axial length compared with the eyes with a longer axial length both at 3 and 6 months of treatment (p = 0.03 and p = 0.04, respectively, ANOVA). CONCLUSION: The hypotensive effect resulting from treatment with latanoprost could be related to ocular axial length.

[Respiratory effects of chronic therapy with latanoprost in patients with chronic obstructive pulmonary disease (COPD)]. / Efectos respiratorios del latanoprost en pacientes con enfermedad pulmonar obstructiva crónica (EPOC).

PURPOSE: To study the respiratory effects of chronic therapy with latanoprost in Chronic Obstructive Pulmonary Disease (COPD) patients. METHODS: We prospectively performed a spirometry in 19 COPD patients treated with latanoprost for more than 3 months, and the same masked-examiner repeated the test, under the same conditions, one week after latanoprost wash-out. RESULTS: We found that latanoprost withdrawal increased forced espiratory volume (FEV1) (litre) from 1.5 S.D. 0.5 to 1.6 S.D. 0.5 and FEV1/FVC (forced vital capacity) index from 64.4 S.D. 8.6% to 66.5 S.D. 7.7% (both comparisons p=0.02, Wilcoxon signed-rank test). CONCLUSION: Chronic therapy with latanoprost seems to induce a mild, though statistically significant, bronchoconstriction in COPD patients.

Efectos respiratorios del latanoprost en pacientes con enfermedad pulmonar obstructiva crónica (epoc) / Respiratory effects of chronic therapy with latanoprost in patients with chronic obstructive pulmonary disease (copd)

Objetivo: Estudiar los efectos respiratorios del tratamiento crónico con latanoprost, en pacientes afectos de enfermedad pulmonar obstructiva crónica (EPOC).Método: Se trata de un estudio prospectivo en el que practicamos una espirometría a 19 pacientes EPOC en tratamiento con latanoprost durante un período de al menos 3 meses y el mismo observador enmascarado repitió el test, en las mismas condiciones, tras una semana de lavado del latanoprost. Resultados: Encontramos que tras la suspensión del latanoprost se produjo un aumento del volumen expulsado en el primer segundo (FEV1) (litros), que pasó de 1,5 D.E. 0,5 a 1,6 D.E. 0,5 y del índice FEV1/FVC (capacidad vital forzada), que se incrementó de 64,4 D.E. 8,6 por ciento a 66,5 D.E. 7,7 por ciento (ambas comparaciones p=0,02, test de Wilcoxon de rangos señalados).Conclusiones: El tratamiento crónico con latanoprost parece inducir un leve, aunque estadísticamente significativo, efecto broncoconstrictor en pacientes afectos de EPOC (AU)

Incidence of iris colour change in latanoprost treated eyes.

AIMS: To determine the incidence of increased iris pigmentation in eyes treated with chronic latanoprost. This is an observational, cohort study. METHODS: The anterior segments of both eyes of 43 patients with glaucoma were photographed after unilateral latanoprost therapy. Two independent, masked observers analysed the slides of both eyes of the study participants, and compared the iris pigmentation of both eyes of each patient using a stereo viewer. RESULTS: 30 patients (69.7%) had a definite acquired iridial anisochromia; 15 patients (50%) had increased superficial iris pigmentation with a "granular" appearance (type 1 change), and 15 patients (50%) had an increased "stromal pigmentation"-that is, the affected iris appeared darker than the fellow eye, but without a "granular" appearance (type 2 change). CONCLUSION: The incidence of increased iris pigmentation induced by latanoprost is much higher than previously reported. The high prevalence of mixed iris colour found in this population and the fact that the patients studied were undergoing unilateral therapy may explain these results.

[Congenital optic nerve pit associated with foveolar retinoschisis]. / Foseta papilar congénita asociada a retinosquisis foveolar.

OBJECTIVE/METHODS: The case of a 36 year old woman who complains of suffering a progressive decrease in visual acuity over a several year period is presented. Her corrected visual acuity was: 1.0 right eye and 0.7 in the left eye. The slit-lamp biomicroscopic examination showed an optic nerve pit in the left eye associated with a transparent schisislike separation of the inner macular retina with a stellate pattern, because of fine folds of the internal limiting membrane. The fluorescein angiography (F.A.) and visual field (V.F.) were normal. RESULTS/CONCLUSION: Congenital optic pits are asymptomatic, unless a serous macular detachment complicates this entity. The characteristic image is an elevation of the neurosensorial retina, a transmission defect in the F.A. and a central scotoma. On the contrary, our patient had a foveolar schisis pattern with normal F.A. and V.F. This macula pattern is rarely associated with a congenital pit.

Foseta papilar congénita asociada a retinosquisis foveolar / Congenital optic nerve pit associated with foveolar retinoschisis

Objetivo/método : Presentamos el caso de una paciente de 36 años de edad que consulta por disminución progresiva de agudeza visual (A.V.) por su ojo izquierdo de años de evolución. La A.V. corregida fue de: 1 ojo derecho (O.D.), 0,7 ojo izquierdo (O.I.). En la exploración a la lámpara de hendidura se apreciaba una foseta papilar asociada a una separación (tipo squisis) de las capas internas retinianas con una estrella macular por pliegues en la membrana limitante interna. La anglografía fluoresceínica (A.F.G.) y el campo visual (C.V.) fueron normales. Resultados/conclusiones: Las fosetas papilares congénitas son asintomáticas, salvo que presenten un desprendimiento seroso macular. La imagen característica es una elevación de la retina neurosensorial, que se traduce en un defecto de transmisión en la A.F.G. y un escotoma central. Nuestra paciente, sin embargo, presentaba el patrón de una squisis foveolar con A.F.G. y C.V. normal, hallazgo éste excepcionalmente asociado a una foseta papilar congénita (AU)

Efecto hipotensor de la pilocarpina en ojos tratados crónicamente con latanoprost; un estudio piloto / Ocular hypotensive effect of pilocarpine in latanoprost treated eyes; a pilot study

Objetivo: Estudiar el efecto hipotensor de la pilocarpina en ojos tratados crónicamente con latanoprost.Métodos: Se midió la PIO de ambos ojos de 25 pacientes antes y después de administrar pilocarpina al 2 por ciento en un ojo, y placebo en el ojo contralateral. Éste es un estudio prospectivo, doble ciego y controlado con placebo.Resultados: Nosotros encontramos que la pilocarpina produjo un cambio tensional en los ojos estudio de +0,4 mmHg en promedio, (rango -3 a +5 mmHg) con respecto a los ojos control, tratados con placebo (p=0,5).Conclusiones: La administración de pilocarpina a ojos tratados crónicamente con latanoprost parece tener un efecto paradójico en la PIO, que puede aumentar o disminuir (AU)

[Ocular hypotensive effect of pilocarpine in latanoprost treated eyes; a pilot study]. / Efecto hipotensor de la pilocarpina en ojos tratados crónicamente con latanoprost; un estudio piloto.

PURPOSE: To study the ocular hypotensive effect of pilocarpine in latanoprost treated eyes. METHODS: We measured the IOP in both eyes of 25 patients, before and after instillation of pilocarpine 2% in one eye, and placebo in the other. This is a prospective, double blind, placebo-controlled study. RESULTS: We found that the mean change in IOP of the study eyes was +0.4 on average (range of change from -3 to +5 mmHg), compared with the control, placebo treated eyes (p=0.5). CONCLUSIONS: The acute administration of pilocarpine in Latanoprost treated eyes seems to have a paradoxical effect on IOP, as the IOP may increase or decrease.